diff --git a/Lib/test/test_embed.py b/Lib/test/test_embed.py
index 7e5e4c14485..16d1c7dea6b 100644
--- a/Lib/test/test_embed.py
+++ b/Lib/test/test_embed.py
@@ -1206,20 +1206,11 @@ def tmpdir_with_python(self, subdir=None):
 
             if MS_WINDOWS:
                 # Copy pythonXY.dll (or pythonXY_d.dll)
-                ver = sys.version_info
-                dll = f'python{ver.major}{ver.minor}'
-                dll3 = f'python{ver.major}'
-                if debug_build(sys.executable):
-                    dll += '_d'
-                    dll3 += '_d'
-                dll += '.dll'
-                dll3 += '.dll'
-                dll = os.path.join(os.path.dirname(self.test_exe), dll)
-                dll3 = os.path.join(os.path.dirname(self.test_exe), dll3)
-                dll_copy = os.path.join(tmpdir, os.path.basename(dll))
-                dll3_copy = os.path.join(tmpdir, os.path.basename(dll3))
-                shutil.copyfile(dll, dll_copy)
-                shutil.copyfile(dll3, dll3_copy)
+                import fnmatch
+                exedir = os.path.dirname(self.test_exe)
+                for f in os.listdir(exedir):
+                    if fnmatch.fnmatch(f, '*.dll'):
+                        shutil.copyfile(os.path.join(exedir, f), os.path.join(tmpdir, f))
 
             # Copy Python program
             exec_copy = os.path.join(tmpdir, os.path.basename(self.test_exe))
diff --git a/Misc/NEWS.d/next/Build/2022-03-23-20-01-16.bpo-47103.b4-00F.rst b/Misc/NEWS.d/next/Build/2022-03-23-20-01-16.bpo-47103.b4-00F.rst
new file mode 100644
index 00000000000..c1e01adce0d
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2022-03-23-20-01-16.bpo-47103.b4-00F.rst
@@ -0,0 +1,2 @@
+Windows ``PGInstrument`` builds now copy a required DLL into the output
+directory, making it easier to run the profile stage of a PGO build.
diff --git a/PCbuild/python.vcxproj b/PCbuild/python.vcxproj
index 11f835aecea..d07db3a6815 100644
--- a/PCbuild/python.vcxproj
+++ b/PCbuild/python.vcxproj
@@ -133,9 +133,6 @@ set PYTHONPATH=$(PySourcePath)Lib
   </Target>
   <Target Name="GeneratePythonBat" AfterTargets="AfterBuild">
     <PropertyGroup>
-      <_PGOPath Condition="$(Configuration) == 'PGInstrument' and $(Platform) == 'Win32'">@set PATH=%PATH%%3B$(VCInstallDir)bin</_PGOPath>
-      <_PGOPath Condition="$(Configuration) == 'PGInstrument' and $(Platform) == 'x64'">@set PATH=%PATH%%3B$(VCInstallDir)bin\amd64</_PGOPath>
-      <_PGOPath Condition="$(Configuration) == 'PGInstrument' and $(VC_PGO_RunTime_Dir) != ''">@set PATH=%PATH%%3B$(VC_PGO_RunTime_Dir)</_PGOPath>
       <_Content>@rem This script invokes the most recently built Python with all arguments
 @rem passed through to the interpreter.  This file is generated by the
 @rem build process and any changes *will* be thrown away by the next
@@ -145,11 +142,21 @@ set PYTHONPATH=$(PySourcePath)Lib
 @echo Running $(Configuration)^|$(Platform) interpreter...
 @setlocal
 @set PYTHONHOME=$(PySourcePath)
-$(_PGOPath)
 @"$(OutDir)python$(PyDebugExt).exe" %*
 </_Content>
       <_ExistingContent Condition="Exists('$(PySourcePath)python.bat')">$([System.IO.File]::ReadAllText('$(PySourcePath)python.bat'))</_ExistingContent>
     </PropertyGroup>
     <WriteLinesToFile File="$(PySourcePath)python.bat" Lines="$(_Content)" Overwrite="true" Condition="'$(_Content)' != '$(_ExistingContent)'" />
   </Target>
+  <Target Name="CopyPGORT" AfterTargets="Link" Condition="$(Configuration) == 'PGInstrument'">
+    <ItemGroup>
+      <_PGORT Include="$(VCToolsInstallDir)bin\Hostx86\x86\pgort140.dll" Condition="$(Platform) == 'Win32'" />
+      <_PGORT Include="$(VCToolsInstallDir)bin\Hostx64\x64\pgort140.dll" Condition="$(Platform) == 'x64'" />
+      <_PGORT Include="$(VCToolsInstallDir)bin\arm64\pgort140.dll" Condition="$(Platform) == 'ARM64'" />
+    </ItemGroup>
+    <Warning Text="Unable to locate pgort140.dll for $(Platform)." Condition="@(_PGORT) == '' or !Exists(@(_PGORT))" />
+    <Copy SourceFiles="@(_PGORT)" DestinationFolder="$(OutDir)">
+      <Output TaskParameter="CopiedFiles" ItemName="FileWrites" />
+    </Copy>
+  </Target>
 </Project>