diff --git a/Lib/_abcoll.py b/Lib/_abcoll.py
index d3e23c1e446..cac06e0825f 100644
--- a/Lib/_abcoll.py
+++ b/Lib/_abcoll.py
@@ -321,18 +321,24 @@ def __iand__(self, it: Iterable):
         return self
 
     def __ixor__(self, it: Iterable):
-        if not isinstance(it, Set):
-            it = self._from_iterable(it)
-        for value in it:
-            if value in self:
-                self.discard(value)
-            else:
-                self.add(value)
+        if it is self:
+            self.clear()
+        else:
+            if not isinstance(it, Set):
+                it = self._from_iterable(it)
+            for value in it:
+                if value in self:
+                    self.discard(value)
+                else:
+                    self.add(value)
         return self
 
     def __isub__(self, it: Iterable):
-        for value in it:
-            self.discard(value)
+        if it is self:
+            self.clear()
+        else:
+            for value in it:
+                self.discard(value)
         return self
 
 MutableSet.register(set)
diff --git a/Lib/test/test_collections.py b/Lib/test/test_collections.py
index da80baa9970..75d660d6287 100644
--- a/Lib/test/test_collections.py
+++ b/Lib/test/test_collections.py
@@ -526,6 +526,21 @@ def __repr__(self):
         s = MySet([5,43,2,1])
         self.assertEqual(s.pop(), 1)
 
+    def test_issue8750(self):
+        empty = WithSet()
+        full = WithSet(range(10))
+        s = WithSet(full)
+        s -= s
+        self.assertEqual(s, empty)
+        s = WithSet(full)
+        s ^= s
+        self.assertEqual(s, empty)
+        s = WithSet(full)
+        s &= s
+        self.assertEqual(s, full)
+        s |= s
+        self.assertEqual(s, full)
+
     def test_Mapping(self):
         for sample in [dict]:
             self.assertIsInstance(sample(), Mapping)
diff --git a/Misc/NEWS b/Misc/NEWS
index 5d234647edd..304977b385c 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -126,6 +126,9 @@ Extensions
 Library
 -------
 
+- Issue #8750: Fixed MutableSet's methods to correctly handle
+  reflexive operations, namely x -= x and x ^= x.
+
 - Issue #9129: smtpd.py is vulnerable to DoS attacks deriving from missing 
   error handling when accepting a new connection.