diff --git a/Mac/BuildScript/build-installer.py b/Mac/BuildScript/build-installer.py
index b07def17476..15a45b95a23 100755
--- a/Mac/BuildScript/build-installer.py
+++ b/Mac/BuildScript/build-installer.py
@@ -363,6 +363,7 @@ def library_recipes():
                             '-DSQLITE_ENABLE_FTS3_PARENTHESIS '
                             '-DSQLITE_ENABLE_JSON1 '
                             '-DSQLITE_ENABLE_RTREE '
+                            '-DSQLITE_OMIT_AUTOINIT '
                             '-DSQLITE_TCL=0 '
                  '%s' % ('','-DSQLITE_WITHOUT_ZONEMALLOC ')[LT_10_5]),
               configure_pre=[
diff --git a/Misc/NEWS.d/next/macOS/2021-04-15-01-20-45.bpo-43851.sDI60Y.rst b/Misc/NEWS.d/next/macOS/2021-04-15-01-20-45.bpo-43851.sDI60Y.rst
new file mode 100644
index 00000000000..0febfb02315
--- /dev/null
+++ b/Misc/NEWS.d/next/macOS/2021-04-15-01-20-45.bpo-43851.sDI60Y.rst
@@ -0,0 +1 @@
+Build SQLite with ``SQLITE_OMIT_AUTOINIT`` on macOS. Patch by Erlend E. Aasland.