diff --git a/Lib/test/test_io.py b/Lib/test/test_io.py
index 32e908da203..b5506b0ac49 100644
--- a/Lib/test/test_io.py
+++ b/Lib/test/test_io.py
@@ -1567,6 +1567,12 @@ def isatty(self):
         pair = self.tp(SelectableIsAtty(True), SelectableIsAtty(True))
         self.assertTrue(pair.isatty())
 
+    def test_weakref_clearing(self):
+        brw = self.tp(self.MockRawIO(), self.MockRawIO())
+        ref = weakref.ref(brw)
+        brw = None
+        ref = None # Shouldn't segfault.
+
 class CBufferedRWPairTest(BufferedRWPairTest):
     tp = io.BufferedRWPair
 
diff --git a/Misc/NEWS b/Misc/NEWS
index 6eb64f95399..e7476e5d2b2 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -16,6 +16,9 @@ Core and Builtins
 Library
 -------
 
+- Issue #22517: When a io.BufferedRWPair object is deallocated, clear its
+  weakrefs.
+
 - Issue #22448: Improve canceled timer handles cleanup to prevent
   unbound memory usage. Patch by Joshua Moore-Oliva.
 
diff --git a/Modules/_io/bufferedio.c b/Modules/_io/bufferedio.c
index 4c0262e25a2..302db0ae135 100644
--- a/Modules/_io/bufferedio.c
+++ b/Modules/_io/bufferedio.c
@@ -2297,6 +2297,8 @@ static void
 bufferedrwpair_dealloc(rwpair *self)
 {
     _PyObject_GC_UNTRACK(self);
+    if (self->weakreflist != NULL)
+        PyObject_ClearWeakRefs((PyObject *)self);
     Py_CLEAR(self->reader);
     Py_CLEAR(self->writer);
     Py_CLEAR(self->dict);