diff --git a/Lib/distutils/unixccompiler.py b/Lib/distutils/unixccompiler.py
index 81a7de61915..081790827d5 100644
--- a/Lib/distutils/unixccompiler.py
+++ b/Lib/distutils/unixccompiler.py
@@ -340,7 +340,9 @@ def find_library_file(self, dirs, lib, debug=0):
             static = os.path.join(dir, static_f)
 
             if sys.platform == 'darwin' and (
-                    dir.startswith('/System/') or dir.startswith('/usr/')):
+                dir.startswith('/System/') or (
+                dir.startswith('/usr/') and not dir.startswith('/usr/local/'))):
+
                 shared = os.path.join(sysroot, dir[1:], shared_f)
                 dylib = os.path.join(sysroot, dir[1:], dylib_f)
                 static = os.path.join(sysroot, dir[1:], static_f)
diff --git a/setup.py b/setup.py
index ab7909e1306..f97fbea1403 100644
--- a/setup.py
+++ b/setup.py
@@ -46,7 +46,7 @@ def is_macosx_sdk_path(path):
     """
     Returns True if 'path' can be located in an OSX SDK
     """
-    return path.startswith('/usr/') or path.startswith('/System/')
+    return (path.startswith('/usr/') and not path.startswith('/usr/local')) or path.startswith('/System/')
 
 def find_file(filename, std_dirs, paths):
     """Searches for the directory where a given file is located,
@@ -862,6 +862,7 @@ class db_found(Exception): pass
                         else:
                             if os.path.isdir(dn):
                                 tmp.append(dn)
+                    db_dirs_to_check = tmp
 
                     db_dirs_to_check = tmp