diff --git a/Misc/NEWS b/Misc/NEWS
index 6df7a6ac0ff..7ab2c77bd91 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -38,6 +38,9 @@ Core and Builtins
 Library
 -------
 
+- Issue #22396: On 32-bit AIX platform, don't expose os.posix_fadvise() nor
+  os.posix_fallocate() because their prototypes in system headers are wrong.
+
 - Issue #22517: When a io.BufferedRWPair object is deallocated, clear its
   weakrefs.
 
diff --git a/Modules/posixmodule.c b/Modules/posixmodule.c
index 473fefaa344..aa2d63ac4ac 100644
--- a/Modules/posixmodule.c
+++ b/Modules/posixmodule.c
@@ -12708,7 +12708,16 @@ os_truncate_impl(PyModuleDef *module, path_t *path, Py_off_t length)
 #endif /* HAVE_TRUNCATE */
 
 
-#ifdef HAVE_POSIX_FALLOCATE
+/* Issue #22396: On 32-bit AIX platform, the prototypes of os.posix_fadvise()
+   and os.posix_fallocate() in system headers are wrong if _LARGE_FILES is
+   defined, which is the case in Python on AIX. AIX bug report:
+   http://www-01.ibm.com/support/docview.wss?uid=isg1IV56170 */
+#if defined(_AIX) && defined(_LARGE_FILES) && !defined(__64BIT__)
+#  define POSIX_FADVISE_AIX_BUG
+#endif
+
+
+#if defined(HAVE_POSIX_FALLOCATE) && !defined(POSIX_FADVISE_AIX_BUG)
 /*[clinic input]
 os.posix_fallocate
 
@@ -12771,10 +12780,10 @@ os_posix_fallocate_impl(PyModuleDef *module, int fd, Py_off_t offset, Py_off_t l
     }
     Py_RETURN_NONE;
 }
-#endif /* HAVE_POSIX_FALLOCATE */
+#endif /* HAVE_POSIX_FALLOCATE) && !POSIX_FADVISE_AIX_BUG */
 
 
-#ifdef HAVE_POSIX_FADVISE
+#if defined(HAVE_POSIX_FADVISE) && !defined(POSIX_FADVISE_AIX_BUG)
 /*[clinic input]
 os.posix_fadvise
 
@@ -12849,7 +12858,7 @@ os_posix_fadvise_impl(PyModuleDef *module, int fd, Py_off_t offset, Py_off_t len
     }
     Py_RETURN_NONE;
 }
-#endif /* HAVE_POSIX_FADVISE */
+#endif /* HAVE_POSIX_FADVISE && !POSIX_FADVISE_AIX_BUG */
 
 #ifdef HAVE_PUTENV