diff --git a/Lib/asyncio/base_events.py b/Lib/asyncio/base_events.py
index 5b5fcde4388..e59b2b75ac1 100644
--- a/Lib/asyncio/base_events.py
+++ b/Lib/asyncio/base_events.py
@@ -351,6 +351,9 @@ def _asyncgen_finalizer_hook(self, agen):
         self._asyncgens.discard(agen)
         if not self.is_closed():
             self.create_task(agen.aclose())
+            # Wake up the loop if the finalizer was called from
+            # a different thread.
+            self._write_to_self()
 
     def _asyncgen_firstiter_hook(self, agen):
         if self._asyncgens_shutdown_called:
diff --git a/Misc/NEWS b/Misc/NEWS
index 4410edadf9a..e508fc15598 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -38,6 +38,8 @@ Library
 
 - Issue #28492: Fix how StopIteration exception is raised in _asyncio.Future.
 
+- Issue #28500: Fix asyncio to handle async gens GC from another thread.
+
 Build
 -----