diff --git a/Lib/unittest/case.py b/Lib/unittest/case.py
index a4a0a1f31e6..ac8d67ddd19 100644
--- a/Lib/unittest/case.py
+++ b/Lib/unittest/case.py
@@ -583,8 +583,11 @@ def run(self, result=None):
             finally:
                 result.stopTest(self)
             return
-        expecting_failure = getattr(testMethod,
-                                    "__unittest_expecting_failure__", False)
+        expecting_failure_method = getattr(testMethod,
+                                           "__unittest_expecting_failure__", False)
+        expecting_failure_class = getattr(self,
+                                          "__unittest_expecting_failure__", False)
+        expecting_failure = expecting_failure_class or expecting_failure_method
         outcome = _Outcome(result)
         try:
             self._outcome = outcome
diff --git a/Lib/unittest/test/test_skipping.py b/Lib/unittest/test/test_skipping.py
index 807510f15f3..71f7b70e479 100644
--- a/Lib/unittest/test/test_skipping.py
+++ b/Lib/unittest/test/test_skipping.py
@@ -120,6 +120,39 @@ def test_die(self):
         self.assertEqual(result.expectedFailures[0][0], test)
         self.assertTrue(result.wasSuccessful())
 
+    def test_expected_failure_with_wrapped_class(self):
+        @unittest.expectedFailure
+        class Foo(unittest.TestCase):
+            def test_1(self):
+                self.assertTrue(False)
+
+        events = []
+        result = LoggingResult(events)
+        test = Foo("test_1")
+        test.run(result)
+        self.assertEqual(events,
+                         ['startTest', 'addExpectedFailure', 'stopTest'])
+        self.assertEqual(result.expectedFailures[0][0], test)
+        self.assertTrue(result.wasSuccessful())
+
+    def test_expected_failure_with_wrapped_subclass(self):
+        class Foo(unittest.TestCase):
+            def test_1(self):
+                self.assertTrue(False)
+
+        @unittest.expectedFailure
+        class Bar(Foo):
+            pass
+
+        events = []
+        result = LoggingResult(events)
+        test = Bar("test_1")
+        test.run(result)
+        self.assertEqual(events,
+                         ['startTest', 'addExpectedFailure', 'stopTest'])
+        self.assertEqual(result.expectedFailures[0][0], test)
+        self.assertTrue(result.wasSuccessful())
+
     def test_expected_failure_subtests(self):
         # A failure in any subtest counts as the expected failure of the
         # whole test.
diff --git a/Misc/NEWS b/Misc/NEWS
index 621b96dc923..fcb06db8ff3 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -79,6 +79,9 @@ Core and Builtins
 Library
 -------
 
+- Issue #21112: Fix regression in unittest.expectedFailure on subclasses.
+  Patch from Berker Peksag.
+
 - Issue #24764: cgi.FieldStorage.read_multi() now ignores the Content-Length
   header in part headers. Patch written by Peter Landry and reviewed by Pierre
   Quentel.